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Virtual Cell Models

Bunne C, Roohani Y, Krause A, Leskovec J · 2024-01-01 · bioRxiv

Generative models for simulating single-cell responses to perturbations.

Overview

The Virtual Cell initiative aims to build generative models that can simulate cellular responses to genetic and chemical perturbations. By learning from large-scale perturb-seq data, these models predict how individual cells change their gene expression programs in response to interventions.

Publication

Building virtual cells with generative AI

Links

📄 Read Paper

Specifications

  • ArchitectureConditional generative model
  • Pretraining DataPerturb-seq datasets
  • ModalityscRNA-seq

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